Oh dude you just have to get the ground to air missile ant it’s easy! I did it with the RPG the first time and it took forever. When you get the ground to air missile, though, you have to make sure you shoot her when she is behind the cathedral tower. She’ll lose a lot of life that way. It took me like 10 mins with the RPG but like 2 with the ground to air missile because it locks on. You can shoot down the helicopters with the searchlight too. Oh and the Patriot Gun is the best for that ride with big mama because you can just keep shooting the whole time and you barely get damaged.